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KMID : 0928320080080010017
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Korean Journal of Health Promotion and Disease Prevention
2008 Volume.8 No. 1 p.17 ~ p.23
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Association of γ-Glutamyltransferase and Inflammatory Markers in Health Screeners at a Health Promotion Center
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Lee Jeong-Gyu
Kim Young-Joo
Lee Sang-Yeoup
Kim Yun-Jin
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Abstract
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Background: Low grade inflammation plays a major role in atherosclerosis, and the measurement of inflammatory markers such as high-sensitivity C-reactive protein (hsCRP) provide methods for risk prediction and reveal independent risk factors of cardiovascular diseases. Gamma-glutamyltransferase(GGT) may directly take part in atherogenesis and can be used potential biochemical risk indicator of cardiovascular disease. The purpose of our study was to assess the correlation between GGT and hsCRP concentration.
Methods: The study subjects consisted of 1,618 individuals who underwent periodic health examination in a university hospital in Busan from June to October 2006. Body mass index, abdominal circumference, blood pressure, and fasting glucose, lipid profile, general blood test, GGT and hsCRP were measured. To quantify the correlation between GGT and hsCRP concentration, partial correlation coefficient were presented.
Results: Total cholesterol(r=0.221, P<0.01), Triglyceride(r=0.431, P<0.01), loghsCRP(r=0.172, P<0.01) showed a significant correlation with GGT level. The GGT was significantly correlated with hsCRP level after adjusting for age, body mass index, abdominal circumference and blood pressure.
Conclusions: These finding suggest that there was a significant correlation between GGT and hsCRP concentration. Therefore, inflammatory status is higher in person who has high level of GGT than a person who has low level. The former is presumed to have a higher risk of atherosclerotic disease thereafter.
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KEYWORD
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gamma-glutamyltransferase, C-Reactive Protein, Inflammation, Atherosclero-sis
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